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APETx2
簡(jiǎn)要描述：Smartox Biotechnology是*一家專(zhuān)門(mén)生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：07APE002- 廠商性質(zhì)：代理商
- 更新時(shí)間：2025-10-25
- 訪 問(wèn) 量：1641
產(chǎn)品介紹
APETx2
ASIC3 selective inhibitor(酸敏感離子通道3 (ASIC3 )選擇性抑制劑) |
APETx2 is a toxin that was originally isolated from Anthopleura elegantissima (Sea anemone). selectively blocks the H(+)-gated sodium channel ASIC3 (ACCN3). The blockage is rapid and reversible. This toxin does not block isoform ASIC1a (unlike Psalmotoxin 1) and isoform ASIC1b of ASIC1 (ACCN2), nor ASIC2 (ACCN1). It also inhibits the heteromeric ASIC2b-ASIC3 channel, and has less affinity for ASIC1b-ASIC3, ASIC1a-ASIC3, and no effect on the ASIC2a-ASIC3 channels. IC50 is 63 nM on ASIC3 channel. IC50 is 117 nM on ASIC2b-ASIC3 heteromeric channel. IC50 is 0.9 µM on ASIC1b-ASIC3 heteromeric channel. IC50 is 2 µM on ASIC1a-ASIC3 heteromeric channel. Interestingly, recent studies demonstrated that also inhibits Nav1.8 currents with an IC50 of around 2 µM.
技術(shù)資料
氨基酸序列：
H-Gly-Thr-Ala-Cys4-Ser-Cys6-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys20-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys30-Arg-Tyr-Phe-Leu-Gly-Thr-Cys37-Cys38-Thr-Pro-Ala-Asp-OH
二硫鍵： Disulfide bonds between Cys4-Cys37, Cys6-Cys30 and Cys20-Cys38
長(zhǎng)度 (aa)：42
分子式： C196H280N54O61S6
分子量： 4561.13 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS 號(hào)： not available
來(lái)源： Synthetic
純度： > 98%
產(chǎn)品信息
07APE002-00100 | 0.1mg | |
07APE002-00500 | 0.5mg | |
07APE002-01000 | 1mg |
